Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22640952 | 0.95 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTABCC4KDM6B | |
| SCHEMBL25587548 | 0.84 | PHF8 (0.42) | MAPTKDM6BKDM5CEGLN1PHF8 | |
| SCHEMBL23196453 | 0.81 | DNM1 (0.45) | ALDH1A1LMNAMAPTTSHR | |
| SCHEMBL18643021 | 0.81 | DNM1 (0.45) | ALDH1A1LMNAMAPTTSHR | |
| SCHEMBL20860759 | 0.80 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM6BKDM5CEGLN1 | |
| SCHEMBL18857631 | 0.79 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTUSP2CYP3A4 | |
| SCHEMBL20000719 | 0.78 | KDM4A (0.38) | ALDH1A1LMNAKDM6BKDM5CEGLN1 | |
| SCHEMBL24556946 | 0.78 | TSHR (0.33) | LMNAKDM6BKDM5CEGLN1PHF8 | |
| SCHEMBL25672058 | 0.78 | KDM6B (0.33) | LMNAMAPTKDM6BKDM5CEGLN1 | |
| SCHEMBL18857622 | 0.77 | MAPT (0.39) | ALDH1A1MAPTKDM6BKDM5CEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145934-B1 | SUBSTITUTED-6,8-DIOXABICYCLO[3.2.1]OCTANE-2,3-DIOL COMPOUNDS AS TARGETING AGENTS OF ASGPR | PFIZER (US) | 2020-11-11 | — | — | EP | disclosed |