Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17077723 | 0.88 | MAPT (0.66) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL6805283 | 0.86 | MAPT (0.70) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL17815792 | 0.83 | MAPT (0.67) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL6797863 | 0.81 | MAPT (0.78) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL5022935 | 0.80 | MAPT (0.68) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL527627 | 0.80 | RAB9A (1.00) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL20603943 | 0.79 | MAPT (0.65) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL30826715 | 0.79 | MAPT (0.64) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL12970394 | 0.79 | MAPT (0.64) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL2177925 | 0.78 | MAPT (0.69) | MAPTNPC1RAB9AMAPK1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116858-B1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2020-11-11 | — | — | EP | disclosed |