Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189916 | 0.78 | LMNA (0.39) | LMNANPC1PDE10AALDH1A1HPGD | |
| SCHEMBL28190661 | 0.78 | LMNA (0.39) | LMNANPC1PDE10AALDH1A1HSD17B10 | |
| SCHEMBL1208751 | 0.73 | — | — | |
| SCHEMBL2616829 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL14119534 | 0.71 | KMT2A (0.34) | COMTLMNANPC1ALDH1A1HPGD | |
| SCHEMBL18759809 | 0.67 | NTRK1 (0.46) | NPC1ALDH1A1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL27621910 | 0.67 | SMN1; SMN2 (0.32) | ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL16470353 | 0.65 | PDE10A (0.42) | COMTPDE10AALDH1A1 | |
| SCHEMBL10282380 | 0.65 | ALDH1A1 (0.42) | COMTPDE10APDE2APDE4DPDE3A | |
| SCHEMBL21182466 | 0.65 | CYP3A4 (0.54) | LMNANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3736277-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | Lupin Limited (IN) | 2020-11-11 | — | — | EP | disclosed |