SCHEMBL22643292

SCHEMBL22643292

Cc1ccc(-c2ccc3c(c2)C(=O)NC3)cc1F

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 3/20 0.62
DYRK1B Q9Y463 2/20 0.62
FYN P06241 1/20 0.62
NTRK1 P04629 2/20 0.61
FLT3 P36888 2/20 0.61
GSK3B P49841 2/20 0.61
DAPK3 O43293 1/20 0.61
PIM1 P11309 1/20 0.61
ROCK1 Q13464 1/20 0.61
NTRK2 Q16620 2/20 0.60
TYRO3 Q06418 1/20 0.60
JAK2 O60674 1/20 0.59
MET P08581 1/20 0.59
FGFR1 P11362 1/20 0.59
PRKACA P17612 1/20 0.59
KDR P35968 1/20 0.59
MAP2K2 P36507 1/20 0.59
MAP2K1 Q02750 1/20 0.59
MST1R Q04912 1/20 0.59
NTRK3 Q16288 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19187116 0.81 CLK4 (0.74) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL29984992 0.81 CLK4 (0.73) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL29985572 0.81 CLK4 (0.74) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL15187776 0.77 CLK4 (0.62) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL12240967 0.77 CLK4 (0.62) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL8264116 0.77 CLK4 (1.00) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL16135668 0.77 CLK4 (0.59) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL25395810 0.76 CLK4 (0.56) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL31346735 0.76 CLK4 (0.56) CLK4DYRK1BFYNNTRK1FLT3
SCHEMBL30915406 0.76 TDP2 (0.59) CLK4DYRK1BFYNNTRK1FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970283-B1 SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C BOEHRINGER INGELHEIM INT (DE) 2020-11-11 EP disclosed