Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 1.00 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.71 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.71 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.61 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | MET | P08581 | 2/20 | 0.60 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | MST1R | Q04912 | 1/20 | 0.60 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680532 | 0.88 | CLK4 (0.78) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL29985572 | 0.85 | CLK4 (0.74) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL19187116 | 0.85 | CLK4 (0.74) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL13618609 | 0.84 | CLK4 (0.73) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL8723086 | 0.83 | CLK4 (1.00) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL30560110 | 0.81 | PARP10 (0.68) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL149199 | 0.81 | PARP10 (0.68) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL23137953 | 0.77 | CLK4 (0.69) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL22643292 | 0.77 | CLK4 (0.62) | CLK4DYRK1BFYNNTRK2TYRO3 | |
| SCHEMBL25920352 | 0.76 | CLK4 (0.73) | CLK4DYRK1BFYNNTRK2TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |