SCHEMBL2264332

SCHEMBL2264332

CN(C)c1cnc(C(=O)NCc2ccc3c(c2)CCN(C2CCC2)CC3)cn1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 14/20 0.54
HRH1 P35367 1/20 0.52
PRKAB2 O43741 1/20 0.39
PRKAG1 P54619 1/20 0.39
PRKAA2 P54646 1/20 0.39
PRKAA1 Q13131 1/20 0.39
PRKAG3 Q9UGI9 1/20 0.39
PRKAG2 Q9UGJ0 1/20 0.39
PRKAB1 Q9Y478 1/20 0.39
CYP2D6 P10635 1/20 0.39
TP53 P04637 1/20 0.38
THRB P10828 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP1A2 P05177 1/20 0.38
POLB P06746 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 1/20 0.38
CYP2C19 P33261 1/20 0.38
ATM Q13315 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269194 0.89 HRH3 (0.49) HRH3HRH1CYP2D6ALDH1A1CYP1A2
SCHEMBL2223911 0.89 HRH3 (0.49) HRH3HRH1CYP2D6ALDH1A1CYP1A2
SCHEMBL1789947 0.87 HRH3 (0.52) HRH3HRH1PRKAB2PRKAG1PRKAA2
SCHEMBL2275230 0.86 HRH3 (0.55) HRH3HRH1PRKAB2PRKAG1PRKAA2
SCHEMBL2264905 0.85 HRH3 (0.49) HRH3HRH1CYP2D6
SCHEMBL1787184 0.83 HRH3 (0.51) HRH3HRH1PRKAB2PRKAG1PRKAA2
SCHEMBL1789860 0.83 HRH3 (0.52) HRH3HRH1TP53CYP1A2CYP2C9
SCHEMBL2347977 0.80 HRH3 (0.49) HRH3HRH1CYP2D6
SCHEMBL2270394 0.80 HRH3 (0.49) HRH3HRH1CYP2D6
SCHEMBL2269745 0.80 HRH3 (0.49) HRH3HRH1PRKAB2PRKAG1PRKAA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011083315-A1 COMPOUNDS AND THEIR USE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-07-14 WO claimed
WO-2011083315-A1 COMPOUNDS AND THEIR USE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-07-14 WO disclosed
WO-2011083315-A1 COMPOUNDS AND THEIR USE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-07-14 WO disclosed