Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275230 | 0.87 | HRH3 (0.55) | HRH3HRH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL5663374 | 0.82 | HRH3 (0.53) | HRH3HRH1CYP2D6 | |
| SCHEMBL2264332 | 0.80 | HRH3 (0.54) | HRH3HRH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1789860 | 0.80 | HRH3 (0.52) | HRH3HRH1 | |
| SCHEMBL2347977 | 0.79 | HRH3 (0.49) | HRH3HRH1CYP2D6ADRA2C | |
| SCHEMBL2270394 | 0.79 | HRH3 (0.49) | HRH3HRH1CYP2D6ADRA2C | |
| SCHEMBL2365248 | 0.79 | HRH3 (0.49) | HRH3HRH1CYP2D6ADRA2C | |
| SCHEMBL2268792 | 0.79 | HRH3 (0.47) | HRH3HRH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1789740 | 0.77 | HRH3 (0.53) | HRH3HRH1CYP2D6 | |
| SCHEMBL1787453 | 0.77 | HRH3 (0.50) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | disclosed |