Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24435590 | 0.85 | HCAR2 (0.38) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL20793908 | 0.73 | HCAR2 (0.43) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL20793787 | 0.70 | HCAR2 (0.40) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL20793786 | 0.70 | HCAR2 (0.40) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL20793788 | 0.70 | HCAR2 (0.40) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL213819 | 0.67 | TSHR (0.57) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL18328175 | 0.67 | TSHR (0.57) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL28159387 | 0.67 | TSHR (0.57) | HCAR2ALDH1A1TP53HSD17B10GABRA1 | |
| SCHEMBL24435591 | 0.67 | HCAR2 (0.40) | HCAR2HSD17B10GRM7CYP1A2CYP2D6 | |
| SCHEMBL28202615 | 0.66 | TSHR (0.55) | HCAR2ALDH1A1TP53HSD17B10GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11274109-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2022-03-15 | — | — | US | disclosed |
| US-20200354382-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11274109-B2 | Boronic acid derivatives | PSMB7, PSMA7, BRD7 | HCAR2 1987/4885ALDH1A1 3525/4885TP53 268/4885 |
| US-20200354382-A1 | Boronic Acid Derivatives | PSMB7, PSMA7, BRD7 | HCAR2 1987/4885ALDH1A1 3525/4885TP53 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.