Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9344185 | 0.76 | TSHR (0.46) | KMT2ACYP1A2TSHR | |
| SCHEMBL27904989 | 0.76 | HCAR2 (0.51) | HCAR2BLMCYP3A4CYP1A2CYP2D6 | |
| SCHEMBL22791458 | 0.74 | HCAR2 (0.46) | HCAR2BLMS1PR5LMNASMN1; SMN2 | |
| SCHEMBL22791138 | 0.72 | LMNA (0.58) | HCAR2KMT2ACYP1A2CYP2D6TSHR | |
| SCHEMBL15106469 | 0.70 | HCAR2 (0.43) | HCAR2BLMKMT2ACYP3A4HSD17B10 | |
| SCHEMBL15106471 | 0.70 | HCAR2 (0.43) | HCAR2BLMKMT2ACYP3A4HSD17B10 | |
| SCHEMBL15111271 | 0.70 | HCAR2 (0.43) | HCAR2BLMKMT2ACYP3A4HSD17B10 | |
| SCHEMBL22791211 | 0.70 | HCAR2 (0.45) | HCAR2BLMCYP3A4CYP1A2CYP2D6 | |
| SCHEMBL22791343 | 0.70 | HCAR2 (0.45) | HCAR2BLMKMT2AHSD17B10S1PR5 | |
| SCHEMBL22791467 | 0.70 | HCAR2 (0.45) | HCAR2BLMCYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858951-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-20220153761-A1 | Boronic Acid Derivatives | MERCK PATENT GMBH (DE) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153761-A1 | Boronic Acid Derivatives | PSMB7, PSMA7, BRD7 | HCAR2 1982/4885GRM7 685/4885BLM 2249/4885 |
| US-11858951-B2 | Boronic acid derivatives | PSMB7, PSMA7, BRD7 | HCAR2 1982/4885GRM7 685/4885BLM 2249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.