Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22647160 | 0.82 | MEN1 (0.55) | SGMS2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL22647212 | 0.82 | NPC1 (0.62) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL22647179 | 0.80 | L3MBTL1 (0.54) | L3MBTL1MEN1KMT2APOLBKDM4E | |
| SCHEMBL11687092 | 0.79 | TDP1 (0.64) | TDP1L3MBTL1BRD4GAASGMS2 | |
| SCHEMBL5936687 | 0.76 | BRD4 (0.65) | TDP1L3MBTL1BRD4GAASGMS2 | |
| SCHEMBL3619403 | 0.76 | BRD4 (0.77) | TDP1L3MBTL1BRD4GAASGMS2 | |
| SCHEMBL11549645 | 0.75 | BRD4 (0.70) | TDP1L3MBTL1BRD4GAASGMS2 | |
| SCHEMBL38660185 | 0.75 | BRD4 (0.70) | TDP1L3MBTL1BRD4GAASGMS2 | |
| SCHEMBL22647194 | 0.75 | HPGD (0.58) | TDP1L3MBTL1MEN1KMT2APOLB | |
| SCHEMBL22647192 | 0.74 | HPGD (0.61) | L3MBTL1BRD4GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227180-A1 | SULFUR AND AMIDE TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2020-11-12 | — | — | WO | disclosed |