Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22647160 | 0.89 | MEN1 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22647194 | 0.83 | HPGD (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL22647157 | 0.82 | TDP1 (0.59) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL11690669 | 0.80 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22192264 | 0.77 | RAB9A (0.94) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL3176173 | 0.77 | FFAR1 (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27918216 | 0.77 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL24438058 | 0.77 | TMPRSS4 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13393187 | 0.76 | RAB9A (0.86) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL4666205 | 0.76 | RAB9A (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227180-A1 | SULFUR AND AMIDE TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2020-11-12 | — | — | WO | disclosed |