⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13181219 | 0.67 | — | — | |
| SCHEMBL703722 | 0.65 | — | — | |
| SCHEMBL19519623 | 0.62 | — | — | |
| SCHEMBL497965 | 0.62 | — | — | |
| SCHEMBL707364 | 0.62 | — | — | |
| SCHEMBL21106521 | 0.62 | — | — | |
| SCHEMBL2370131 | 0.61 | ALDH1A1 (0.37) | — | |
| SCHEMBL11778486 | 0.61 | ABCB11 (0.31) | — | |
| SCHEMBL19722741 | 0.61 | — | — | |
| SCHEMBL704007 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230023761-A1 | SUBSTITUTED PYRIDINES AS TYK2 INHIBITORS | ALUMIS INC. | 2023-01-26 | — | — | US | disclosed |
| US-11053219-B2 | Substituted pyridines as TYK2 inhibitors | ESKER THERAPEUTICS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200354338-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2020-11-12 | — | — | US | disclosed |