Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13756247 | 0.86 | RAB9A (0.81) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL10756539 | 0.83 | MDM2 (0.50) | MDM2KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL10854635 | 0.83 | MDM2 (0.55) | MDM2KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL10020286 | 0.81 | MDM2 (1.00) | MDM2KMT2ARAB9AMEN1TAAR1 | |
| SCHEMBL10625584 | 0.80 | NPC1 (0.53) | MDM2KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL9285165 | 0.80 | NPC1 (0.67) | KMT2ARAB9AMEN1NPC1TAAR1 | |
| SCHEMBL31668740 | 0.79 | MDM2 (0.95) | MDM2KMT2ARAB9AMEN1TAAR1 | |
| SCHEMBL12156880 | 0.79 | RAB9A (0.62) | KMT2ARAB9AMEN1NPC1TAAR1 | |
| SCHEMBL5852111 | 0.78 | RAB9A (0.70) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL15946352 | 0.78 | EPHX2 (0.72) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | XBP1, RNASE1, ERN1 | MDM2 2218/4885KMT2A 3822/4885RAB9A 2652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.