Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544532 | 0.84 | TP53 (0.52) | NOTUMTP53ACLYNPC1RAB9A | |
| SCHEMBL24092055 | 0.84 | TP53 (0.52) | NOTUMTP53ACLYNPC1RAB9A | |
| SCHEMBL8293860 | 0.81 | NOTUM (0.67) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL12477652 | 0.80 | NOTUM (0.69) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL102648 | 0.79 | TP53 (0.47) | NOTUMTP53ACLYNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5656477 | 0.78 | NOTUM (0.67) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14153507 | 0.78 | NPC1 (0.57) | NOTUMTP53ACLYTAAR1NPC1 | |
| SCHEMBL12704747 | 0.78 | CHRNB2 (0.53) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14153029 | 0.76 | NPC1 (0.74) | TP53NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL2360819 | 0.76 | L3MBTL1 (0.77) | TP53NPC1RAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |