Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 5/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22637645 | 0.82 | KLKB1 (0.44) | GRNSORT1KDM4EKLKB1POLB | |
| SCHEMBL22649482 | 0.81 | GRN (0.61) | GRNSORT1KDM4EKLKB1POLB | |
| SCHEMBL22437129 | 0.72 | MEN1 (0.41) | GRNSORT1KDM4EPOLBALDH1A1 | |
| SCHEMBL950617 | 0.71 | KLKB1 (0.46) | GRNSORT1KDM4EKLKB1POLB | |
| SCHEMBL30961174 | 0.69 | GRN (0.41) | GRNSORT1KDM4EKLKB1POLB | |
| SCHEMBL22637363 | 0.68 | ALDH1A1 (0.39) | GRNSORT1KDM4EALDH1A1GAA | |
| SCHEMBL22649229 | 0.68 | GRN (0.64) | GRNSORT1KDM4EKLKB1POLB | |
| SCHEMBL12559873 | 0.66 | KLKB1 (0.41) | GRNSORT1KDM4EKLKB1POLB | |
| SCHEMBL22637750 | 0.65 | HPGD (0.41) | KDM4EPOLBALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL8932269 | 0.64 | GRN (0.69) | GRNSORT1KDM4EKLKB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |