Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.53 |
| ▸ | CCND1 | P24385 | 4/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.53 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 9/20 | 0.37 |
| ▸ | JAK1 | P23458 | 7/20 | 0.37 |
| ▸ | TYK2 | P29597 | 7/20 | 0.37 |
| ▸ | JAK3 | P52333 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650556 | 0.87 | CDK4 (0.52) | CDK4CCND1CDK6BMPR2JAK2 | |
| SCHEMBL22650753 | 0.85 | CDK4 (0.51) | CDK4CCND1CDK6BMPR2JAK2 | |
| SCHEMBL22650754 | 0.85 | CDK4 (0.51) | CDK4CCND1CDK6BMPR2JAK2 | |
| SCHEMBL22650761 | 0.85 | CDK4 (0.51) | CDK4CCND1CDK6BMPR2JAK2 | |
| SCHEMBL22650551 | 0.79 | CDK6 (0.52) | CDK4CCND1CDK6JAK2NPC1 | |
| SCHEMBL22650445 | 0.78 | CDK4 (0.60) | CDK4CCND1CDK6CDK2CCNA2 | |
| SCHEMBL22650544 | 0.78 | CDK4 (0.56) | CDK4CCND1CDK6BMPR2JAK2 | |
| SCHEMBL22650553 | 0.77 | CDK6 (0.51) | CDK4CCND1CDK6BMPR2CDK2 | |
| SCHEMBL22650444 | 0.77 | CDK4 (0.50) | CDK4CCND1CDK6CDK2CCNA2 | |
| SCHEMBL22650545 | 0.77 | CDK4 (0.55) | CDK4CCND1CDK6BMPR2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |