Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.67 |
| ▸ | PIM1 | P11309 | 3/20 | 0.67 |
| ▸ | PRKACA | P17612 | 3/20 | 0.67 |
| ▸ | CLK2 | P49760 | 3/20 | 0.67 |
| ▸ | GSK3B | P49841 | 3/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.67 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.67 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.67 |
| ▸ | PRKCG | P05129 | 2/20 | 0.67 |
| ▸ | CDK1 | P06493 | 2/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.67 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.67 |
| ▸ | CDK2 | P24941 | 2/20 | 0.67 |
| ▸ | MARK3 | P27448 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | FLT4 | P35916 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324729 | 0.89 | CHEK1 (0.63) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL18129791 | 0.89 | CHEK1 (0.63) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL18129591 | 0.87 | CHEK1 (0.67) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1849976 | 0.85 | CHEK1 (0.69) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL4053840 | 0.85 | CHEK1 (0.61) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3612538 | 0.84 | TMEM97 (0.65) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL2267096 | 0.84 | CHEK1 (0.58) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL18129469 | 0.84 | CHEK1 (0.62) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1850198 | 0.83 | CHEK1 (0.62) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL18129558 | 0.83 | CHEK1 (0.67) | CHEK1MAP4K4PIM1PRKACACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239873-B2 | 7-azaindole or 4,7-diazaindole derivatives as IKKϵ epsilon and TBK1 inhibitor and pharmaceutical composition comprising same | GREEN CROSS CORPORATION (KR) | 2019-03-26 | — | — | US | disclosed |
| US-20160297815-A1 | 7-AZAINDOLE OR 4,7-DIAZAINDOLE DERIVATIVES AS IKK EPSILON AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GREEN CROSS CORPORATION (KR) | 2016-10-13 | — | — | US | disclosed |
| US-8003649-B2 | Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155 | ASTRAZENECA AB (SE) | 2011-08-23 | — | — | US | disclosed |
| CN-101952286-A | Bicyclic derivatives for use in the treatment of androgen receptor associated conditions | ASTRAZENECA AB | 2011-01-19 | — | — | CN | disclosed |
| US-20100016279-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS-155 | ASTRAZENECA AB (SE) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297815-A1 | 7-AZAINDOLE OR 4,7-DIAZAINDOLE DERIVATIVES AS IKK EPSILON AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | TANK, NFKBIA, TBK1 | CHEK1 121/4885MAP4K4 882/4885PIM1 858/4885 |
| US-10239873-B2 | 7-azaindole or 4,7-diazaindole derivatives as IKKϵ epsilon and TBK1 inhibitor and pharmaceutical composition comprising same | NFKBIA, TANK, TBK1 | CHEK1 120/4885MAP4K4 995/4885PIM1 675/4885 |
| US-20100016279-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS-155 | AR, NR5A1, CYP17A1 | CHEK1 3415/4885MAP4K4 3925/4885PIM1 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.