Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | CCND1 | P24385 | 2/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | BCR | P11274 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650742 | 0.77 | TRPV1 (0.40) | CDK4CCND1CDK6 | |
| SCHEMBL18081432 | 0.75 | CDK6 (0.55) | CDK4CCND1CDK6SMN1; SMN2MAPT | |
| SCHEMBL22650762 | 0.73 | CDK6 (0.67) | CDK4CCND1CDK6 | |
| SCHEMBL22650544 | 0.73 | CDK4 (0.56) | CDK4CCND1CDK6SMN1; SMN2 | |
| SCHEMBL22650545 | 0.72 | CDK4 (0.55) | CDK4CCND1CDK6SMN1; SMN2 | |
| SCHEMBL22650555 | 0.71 | CDK6 (1.00) | CDK4CCND1CDK6 | |
| SCHEMBL22650552 | 0.70 | CDK4 (0.53) | CDK4CCND1CDK6SMN1; SMN2 | |
| SCHEMBL18081435 | 0.70 | MAPT (0.53) | CDK4CCND1CDK6SMN1; SMN2MAPT | |
| SCHEMBL19773558 | 0.69 | SMN1; SMN2 (0.45) | CDK4CCND1CDK6SMN1; SMN2MAPT | |
| SCHEMBL24817958 | 0.68 | CDK4 (0.35) | CDK4CCND1CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |