SCHEMBL22650762

SCHEMBL22650762

CC(C)N1CCN(c2ccc(Nc3ncc(F)c(N4CCc5ncn(C(C)C)c5C4)n3)nc2)CC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK6 Q00534 14/20 0.67
CDK4 P11802 14/20 0.67
CCND1 P24385 9/20 0.67
CCND3 P30281 7/20 0.46
CCNA2 P20248 6/20 0.46
CDK1 P06493 4/20 0.46
CDK2 P24941 4/20 0.41
CCNE1 P24864 1/20 0.41
CDK9 P50750 4/20 0.41
CCNT1 O60563 2/20 0.41
CCNH P51946 2/20 0.41
CTSC P53634 1/20 0.41
TTK P33981 1/20 0.41
FLT3 P36888 1/20 0.41
NEK10 Q6ZWH5 1/20 0.41
ULK2 Q8IYT8 1/20 0.41
NUAK2 Q9H093 1/20 0.41
CCNK O75909 2/20 0.40
CDK7 P50613 1/20 0.40
MNAT1 P51948 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650447 0.83 CDK4 (0.60) CDK6CDK4CCND1CCND3CCNA2
SCHEMBL22650445 0.83 CDK4 (0.60) CDK6CDK4CCND1CCND3CCNA2
SCHEMBL22650555 0.80 CDK6 (1.00) CDK6CDK4CCND1CCND3CCNA2
SCHEMBL22650551 0.75 CDK6 (0.52) CDK6CDK4CCND1CCNA2CDK1
SCHEMBL22650552 0.75 CDK4 (0.53) CDK6CDK4CCND1CCND3CCNA2
SCHEMBL22650556 0.74 CDK4 (0.52) CDK6CDK4CCND1CCND3CCNA2
SCHEMBL22650544 0.74 CDK4 (0.56) CDK6CDK4CCND1CCNA2CDK1
SCHEMBL22650749 0.73 CDK4 (0.54) CDK6CDK4CCND1
SCHEMBL22650545 0.73 CDK4 (0.55) CDK6CDK4CCND1CDK1CDK2
SCHEMBL18081375 0.73 CDK4 (0.65) CDK6CDK4CCND1CCND3CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed