Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 14/20 | 0.40 |
| ▸ | CDK4 | P11802 | 13/20 | 0.40 |
| ▸ | CDK2 | P24941 | 9/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.40 |
| ▸ | CDK1 | P06493 | 7/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.40 |
| ▸ | CCND3 | P30281 | 4/20 | 0.40 |
| ▸ | CDK7 | P50613 | 4/20 | 0.40 |
| ▸ | CCNH | P51946 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29491176 | 1.00 | DYRK2 (0.42) | DYRK2CCND1CDK4CDK2CCNA2 | |
| SCHEMBL31589820 | 1.00 | DYRK2 (0.42) | DYRK2CCND1CDK4CDK2CCNA2 | |
| SCHEMBL22650787 | 0.80 | CDK4 (0.47) | CCND1CDK4CDK2CCNA2CDK6 | |
| SCHEMBL22650497 | 0.74 | DYRK2 (0.47) | DYRK2CCND1CDK4CDK2CCNA2 | |
| SCHEMBL29462408 | 0.74 | DYRK2 (0.47) | DYRK2CCND1CDK4CDK2CCNA2 | |
| SCHEMBL29250206 | 0.71 | DYRK2 (0.52) | DYRK2CCND1CDK4CDK2CCNA2 | |
| SCHEMBL4903043 | 0.71 | GPR119 (0.41) | DYRK2CCNT1ENPP2 | |
| SCHEMBL31590654 | 0.70 | DYRK2 (0.42) | DYRK2CCND1CDK4CDK2CCNA2 | |
| SCHEMBL22363229 | 0.70 | CDK4 (0.70) | CCND1CDK4CDK6 | |
| SCHEMBL29551980 | 0.69 | TYK2 (0.57) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |