Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 6/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 12/20 | 0.40 |
| ▸ | CCND3 | P30281 | 5/20 | 0.40 |
| ▸ | CDK4 | P11802 | 11/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29462408 | 1.00 | DYRK2 (0.47) | DYRK2CDK6CCND3CDK4CSF1R | |
| SCHEMBL22650492 | 0.81 | CDK6 (0.58) | CDK6CCND3CDK4CSF1RPIK3CD | |
| SCHEMBL22650772 | 0.81 | CDK6 (0.46) | CDK6CCND3CDK4CSF1RPIK3CD | |
| SCHEMBL22650773 | 0.80 | CDK4 (0.45) | CDK6CCND3CDK4CSF1RCCNA2 | |
| SCHEMBL22650509 | 0.79 | CDK6 (0.48) | CDK6CCND3CDK4CSF1RPIK3CD | |
| SCHEMBL21245536 | 0.77 | CDK4 (0.69) | CDK6CDK4CSF1RPIK3CDCCNA2 | |
| SCHEMBL22650507 | 0.75 | CDK6 (0.45) | CDK6CCND3CDK4CSF1RCCNA2 | |
| SCHEMBL22650784 | 0.74 | DYRK2 (0.42) | DYRK2CDK6CCND3CDK4CCNA2 | |
| SCHEMBL31589820 | 0.74 | DYRK2 (0.42) | DYRK2CDK6CCND3CDK4CCNA2 | |
| SCHEMBL29491176 | 0.74 | DYRK2 (0.42) | DYRK2CDK6CCND3CDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114364675-A | CDK inhibitors | 上海齐鲁锐格医药研发有限公司 | 2022-04-15 | — | — | CN | disclosed |
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |