Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484248 | 0.88 | ALK (0.54) | MAPTKDM4EHPGDTNKSMEN1 | |
| SCHEMBL22652030 | 0.83 | BMI1 (0.49) | MAPTMEN1KMT2AALKLMNA | |
| SCHEMBL22651970 | 0.83 | RAB9A (0.56) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL22652032 | 0.75 | KMT2A (0.50) | MAPTKDM4EHPGDTNKSMEN1 | |
| SCHEMBL2163053 | 0.74 | PTPN1 (0.44) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL22638069 | 0.70 | MAPK8 (0.53) | MAPTKDM4EHPGDKMT2AALDH1A1 | |
| SCHEMBL2164490 | 0.70 | MAPK8 (0.37) | KDM4EHPGDALDH1A1LCK | |
| SCHEMBL22648887 | 0.70 | LCK (0.51) | KDM4EHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL22638077 | 0.70 | RAB9A (0.43) | MAPTKDM4EHPGDMEN1KMT2A | |
| SCHEMBL11471226 | 0.70 | KDM4E (0.58) | MAPTKDM4EHPGDTNKSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227576-A1 | REGIO-SELECTIVE SYNTHESIS OF IMIDAZO[1,2-A]PYRIMIDINES | GENENTECH, INC. (US) | 2020-11-12 | — | — | WO | disclosed |