Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22651969 | 0.88 | MAPT (0.46) | ALKSMN1; SMN2MAPK1LCKLMNA | |
| SCHEMBL22652030 | 0.85 | BMI1 (0.49) | ALKSMN1; SMN2LMNARAB9AMAPT | |
| SCHEMBL22651970 | 0.85 | RAB9A (0.56) | ALKSMN1; SMN2LMNAHPGDRAB9A | |
| SCHEMBL22652032 | 0.80 | KMT2A (0.50) | SMN1; SMN2MAPK1LCKLMNAHPGD | |
| SCHEMBL22638069 | 0.78 | MAPK8 (0.53) | SMN1; SMN2LCKHPGDRAB9ANPC1 | |
| SCHEMBL2164490 | 0.75 | MAPK8 (0.37) | LCKHPGDPOLBKDM4EPTPN2 | |
| SCHEMBL22648887 | 0.75 | LCK (0.51) | LCKHPGDKDM4EMEN1KMT2A | |
| SCHEMBL31346253 | 0.73 | SMN1; SMN2 (0.52) | ALKSMN1; SMN2HSD17B10MAPK1LCK | |
| SCHEMBL12403047 | 0.73 | MAPK8 (0.55) | SMN1; SMN2LCKLMNAKDM4EKMT2A | |
| SCHEMBL29892431 | 0.72 | KDM4E (0.49) | HSD17B10LMNAHPGDRAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227576-A1 | REGIO-SELECTIVE SYNTHESIS OF IMIDAZO[1,2-A]PYRIMIDINES | GENENTECH, INC. (US) | 2020-11-12 | — | — | WO | disclosed |
| EP-2411057-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | Siemens Medical Solutions USA, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111303-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-30 | — | — | WO | disclosed |