Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 5/20 | 0.36 |
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | FYN | P06241 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701517 | 0.82 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL3708672 | 0.79 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL3711032 | 0.75 | ESR1 (0.45) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL1709838 | 0.75 | SYK (0.37) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL3709003 | 0.73 | APP (0.37) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL1709887 | 0.72 | SYK (0.51) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL3713429 | 0.71 | XDH (0.37) | PDE4APDE4BPDE4CPDE4DAPP | |
| SCHEMBL3715489 | 0.70 | SYK (0.41) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL3712321 | 0.69 | TLR7 (0.39) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL31690997 | 0.69 | APP (0.67) | PDE4APDE4BPDE4CPDE4DAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | PDE4A 537/4885PDE4B 703/4885PDE4C 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.