Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cis-Urocanic Acid SCHEMBL2265413 | 1.00 | KDM4E (0.40) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL1311341 | 0.94 | KDM4E (0.43) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL19031717 | 0.94 | KDM4E (0.43) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL15418 | 0.94 | KDM4E (0.43) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL1755678 | 0.94 | KDM4E (0.43) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL15417 | 0.94 | KDM4E (0.43) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL7715148 | 0.93 | KDM4E (0.42) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL7715147 | 0.93 | KDM4E (0.42) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL11477131 | 0.93 | KDM4E (0.42) | KDM4ENPSR1CYP3A4BLMTSHR | |
| Cis-Urocanic Acid SCHEMBL20554993 | 0.87 | KDM4E (0.36) | KDM4ENPSR1CYP3A4BLMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190267-A1 | PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE PHARMACEUTICALS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190267-A1 | PRODRUGS OF OPIOIDS AND USES THEREOF | OPRK1, OPRL1, OPRM1 | KDM4E 1479/4885NPSR1 28/4885CYP3A4 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.