Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 7/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 6/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265477 | 1.00 | SLC7A5 (0.44) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| SCHEMBL9087108 | 0.82 | SLC7A5 (0.44) | SLC7A5GRIK1SLC1A2SLC1A3SLC1A1 | |
| SCHEMBL197117 | 0.80 | SLC7A5 (0.48) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| SCHEMBL197139 | 0.80 | SLC7A5 (0.48) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| SCHEMBL196695 | 0.80 | SLC7A5 (0.48) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| SCHEMBL127215 | 0.79 | GRIK1 (0.46) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| SCHEMBL1332891 | 0.79 | GRIK1 (0.46) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| SCHEMBL29179644 | 0.79 | GRIK1 (0.46) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| SCHEMBL2424261 | 0.78 | SLC7A5 (0.46) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 | |
| Hydrochloric Acid SCHEMBL21059082 | 0.78 | SLC7A5 (0.46) | SLC7A5GRIK1PTGS1SLC7A11SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445440-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2013-05-21 | — | — | US | disclosed |
| EP-2539333-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104266-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-08-25 | — | — | US | disclosed |
| EP-1537089-A4 | COMPOUNDS COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2008-04-16 | — | — | EP | disclosed |
| US-20080021050-A1 | Compounds, compositions, and methods | CYTOKINETICS, INC. | 2008-01-24 | — | — | US | disclosed |
| US-7211580-B2 | Compounds, compositions, and methods | CYTOKINETICS, INCORPORATED (US) | 2007-05-01 | — | — | US | disclosed |
| EP-1537089-A2 | COMPOUNDS COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040142949-A1 | Compounds, compositions, and methods | CYTOKINETICS, INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004009036-A2 | COMPOUNDS COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021050-A1 | Compounds, compositions, and methods | ALPP, PCNA, MKI67 | SLC7A5 4191/4885GRIK1 1527/4885PTGS1 2189/4885 |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | SLC7A5 3081/4885GRIK1 4494/4885PTGS1 3021/4885 |
| US-20040142949-A1 | Compounds, compositions, and methods | ALPP, PCNA, MKI67 | SLC7A5 4191/4885GRIK1 1527/4885PTGS1 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.