Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28979284 | 0.81 | GAA (0.52) | ALDH1A1CYP1A2GAALMNAHPGD | |
| SCHEMBL13263371 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP1A2GAALMNATSHR | |
| SCHEMBL15286415 | 0.80 | ALDH1A1 (0.46) | ALDH1A1CYP1A2GAALMNATSHR | |
| SCHEMBL29660779 | 0.80 | ALDH1A1 (0.62) | ALDH1A1CYP1A2GAALMNAHPGD | |
| SCHEMBL5731919 | 0.79 | MEN1 (0.45) | ALDH1A1CYP1A2GAALMNAHPGD | |
| SCHEMBL11869242 | 0.79 | ALDH1A1 (0.45) | ALDH1A1CYP1A2GAALMNATSHR | |
| SCHEMBL2827636 | 0.79 | ALDH1A1 (0.53) | ALDH1A1CYP1A2GAALMNAHPGD | |
| SCHEMBL22658875 | 0.79 | ALDH1A1 (0.45) | ALDH1A1CYP1A2GAALMNATSHR | |
| SCHEMBL2832750 | 0.76 | ALDH1A1 (0.48) | ALDH1A1GAALMNAHPGDKDM4E | |
| SCHEMBL28688872 | 0.75 | GAA (0.44) | ALDH1A1CYP1A2GAATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3965803-B1 | SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS | DANA FARBER CANCER INST INC (US) | 2025-08-20 | — | — | EP | disclosed |
| US-12365696-B2 | Small-molecule focal adhesion kinase (FAK) inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| US-20220242882-A1 | SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-08-04 | — | — | US | disclosed |
| EP-3965803-A1 | SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS | Dana-Farber Cancer Institute, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |
| CN-113811324-A | Small molecule Focal Adhesion Kinase (FAK) inhibitors | 达纳-法伯癌症研究公司 | 2021-12-17 | — | — | CN | disclosed |
| WO-2020231726-A1 | SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12365696-B2 | Small-molecule focal adhesion kinase (FAK) inhibitors | PTK2, CTTN, TNK2 | ALDH1A1 2836/4885CYP1A2 4860/4885GAA 2773/4885 |
| US-20220242882-A1 | SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS | PTK2, CTTN, TNK2 | ALDH1A1 2836/4885CYP1A2 4860/4885GAA 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.