Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 8/20 | 0.85 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808801 | 1.00 | DHODH (0.85) | DHODHFNTAFNTBEPHX2TRPV1 | |
| Teriflunomide SCHEMBL22661 | 0.92 | DHODH (1.00) | DHODHEPHX2TRPV1 | |
| Teriflunomide SCHEMBL993119 | 0.92 | DHODH (1.00) | DHODHEPHX2TRPV1 | |
| Teriflunomide SCHEMBL20214092 | 0.92 | DHODH (1.00) | DHODHEPHX2TRPV1 | |
| Teriflunomide SCHEMBL2760666 | 0.92 | DHODH (1.00) | DHODHEPHX2TRPV1 | |
| Teriflunomide SCHEMBL991312 | 0.91 | DHODH (0.97) | DHODHEPHX2TRPV1 | |
| Teriflunomide SCHEMBL8466730 | 0.91 | DHODH (0.97) | DHODHEPHX2TRPV1 | |
| Teriflunomide SCHEMBL992140 | 0.91 | DHODH (0.97) | DHODHEPHX2TRPV1 | |
| SCHEMBL9178600 | 0.88 | DHODH (0.66) | DHODHFNTAFNTBEPHX2TRPV1 | |
| SCHEMBL9081065 | 0.87 | DHODH (0.64) | DHODHFNTAFNTBEPHX2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | disclosed |