Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Teriflunomide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH known ✓ | Q02127 | 9/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Teriflunomide SCHEMBL2760666 | 1.00 | DHODH (1.00) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL20214092 | 1.00 | DHODH (1.00) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL22661 | 1.00 | DHODH (1.00) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL8466730 | 0.99 | DHODH (0.97) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL991312 | 0.99 | DHODH (0.97) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL992140 | 0.99 | DHODH (0.97) | DHODHEPHX2TRPV1NPC1RAB9A | |
| SCHEMBL9079302 | 0.92 | DHODH (0.85) | DHODHEPHX2TRPV1 | |
| SCHEMBL8808801 | 0.92 | DHODH (0.85) | DHODHEPHX2TRPV1 | |
| SCHEMBL12312432 | 0.90 | DHODH (0.82) | DHODHALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL8404982 | 0.88 | DHODH (0.79) | DHODHEPHX2TRPV1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 485 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114288294-A | Compounds and methods for treating or preventing hematologic cancers | 布罗德研究所股份有限公司 | 2022-04-08 | — | — | CN | claimed |
| US-20210290585-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH CORTICO-HIPPOCAMPAL HYPERACTIVITY | UNIV RAMOT (IL) | 2021-09-23 | — | — | US | claimed |
| US-11033524-B2 | Methods and compositions for treating disorders associated with cortico-hippocampal hyperactivity | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2021-06-15 | — | — | US | claimed |
| EP-3310755-B1 | A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE | BIOCON LTD (IN) | 2021-02-24 | — | — | EP | claimed |
| EP-3344243-B1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS | BROAD INST INC (US) | 2020-12-09 | — | — | EP | claimed |
| US-20190269644-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH CORTICO-HIPPOCAMPAL HYPERACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2019-09-05 | — | — | US | claimed |
| US-20180263970-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS | THE BROAD INSTITUTE, INC. (US) | 2018-09-20 | — | — | US | claimed |
| EP-3344243-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS | The Broad Institute Inc. (US) | 2018-07-11 | — | — | EP | claimed |
| US-20180170859-A1 | A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE | BIOCON LIMITED (IN) | 2018-06-21 | — | — | US | claimed |
| EP-3310755-A1 | A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE | Biocon Limited (IN) | 2018-04-25 | — | — | EP | claimed |
| EP-0787491-A1 | PREVENTIVE AND REMEDY FOR TYPE I ALLERGIC DISEASES | HOECHST JAPAN LIMITED (JP) | 1997-08-06 | — | — | EP | claimed |
| US-5624946-A | Use of leflunomide to control and reverse chronic allograft rejection | WILLIAMS, JAMES W. | 1997-04-29 | — | — | US | claimed |
| EP-0527736-B1 | ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS | HOECHST AG (DE) | 1997-04-16 | — | — | EP | claimed |
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | claimed |
| US-5519042-A | Method of treating hyperproliferative vascular disease | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-21 | — | — | US | claimed |
| US-5504084-A | N-(4-TRIFLUOROMETHYLPHENYL) SUBSTITUTION ON 5-METHYL-ISOXAZOLE-4-CARBOXAMIDE OR 2-CYANO-3-HYDROXYCROTONAMIDE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | claimed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | claimed |
| US-5459163-A | Treatment of lupus, graft-versus-host diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-17 | — | — | US | claimed |
| EP-0665013-A1 | Method of treating hyperproliferative vascular disease | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-02 | — | — | EP | claimed |
| EP-0617959-A1 | Pharmaceutical for the treatment of skin disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-05 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170859-A1 | A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE | TMT1A, FAR1, CYP51A1 | DHODH 15/4885EPHX2 1257/4885TRPV1 4005/4885 |
| US-20180263970-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS | DHODH, MCL1, DHX15 | DHODH 1/4885EPHX2 57/4885TRPV1 4759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.