Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19988469 | 0.88 | MAP2K1 (0.42) | MAPTACHEGABRA1GABRG2GABRB3 | |
| SCHEMBL22666135 | 0.81 | PTK6 (0.36) | MAPTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL21155932 | 0.78 | MAPT (0.43) | MAPTACHEGABRA1GABRG2GABRB3 | |
| SCHEMBL19988466 | 0.77 | KDM4E (0.44) | MAPTACHEGABRA1GABRG2GABRB3 | |
| SCHEMBL19988450 | 0.74 | CSNK2A1 (0.42) | MAPTACHEGABRA1GABRG2GABRB3 | |
| SCHEMBL19988459 | 0.68 | KDM4E (0.44) | MAPTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL19988468 | 0.68 | MAP2K1 (0.49) | MAPTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL19988799 | 0.67 | KDM4E (0.47) | MAPTACHEGABRA1GABRG2GABRB3 | |
| SCHEMBL19988470 | 0.66 | ACHE (0.46) | MAPTACHEGABRA1GABRG2GABRB3 | |
| SCHEMBL6645026 | 0.66 | ACHE (0.74) | MAPTACHEGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512848-B1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-18 | — | — | EP | disclosed |