Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.74 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GABRP | O00591 | 1/20 | 0.59 |
| ▸ | GABRD | O14764 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | TOP1 | P11387 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norharmane SCHEMBL29145728 | 0.90 | CHUK (0.74) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12590218 | 0.90 | ACHE (0.61) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29568550 | 0.86 | PARP1 (0.67) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29382084 | 0.86 | ACHE (1.00) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29601450 | 0.86 | PARP1 (0.67) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL121401 | 0.86 | ACHE (1.00) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1009117 | 0.86 | PARP1 (0.67) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29277816 | 0.84 | PARP1 (0.65) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL3234011 | 0.84 | ACHE (0.96) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL4436954 | 0.84 | ACHE (0.96) | ACHEGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427729-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NPY5 RECEPTOR ANTAGONISTS | Astrazeneca AB (SE) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022849-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NPY5 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-03-20 | — | — | WO | disclosed |