Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.58 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.58 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30404925 | 1.00 | ALDH1A1 (0.58) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL22667293 | 0.92 | ALDH1A1 (0.60) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL30404094 | 0.92 | ALDH1A1 (0.60) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL4292310 | 0.82 | CUL4A (0.62) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL29011253 | 0.82 | ALDH1A1 (0.63) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL28606638 | 0.82 | CES1 (0.65) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL11147994 | 0.81 | ALDH1A1 (0.62) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL21001752 | 0.81 | ALDH1A1 (0.65) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL29011247 | 0.80 | ALDH1A1 (0.60) | ALDH1A1ALDH2ALDH3A1CUL4AACHE | |
| SCHEMBL16064931 | 0.80 | ALDH1A1 (0.47) | ALDH1A1ALDH2ALDH3A1CUL4AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111433195-B | Pyridone derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| US-11160797-B2 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2021-11-02 | — | — | US | disclosed |
| US-20200360357-A1 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2020-11-19 | — | — | US | disclosed |
| CN-111433195-A | Pyridone derivatives and their use as selective A L K-2 inhibitors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200360357-A1 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | ALK, ACVR2B, ACVR1B | ALDH1A1 118/4885ALDH2 445/4885ALDH3A1 269/4885 |
| US-11160797-B2 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | ALK, ACVR2B, ACVR1B | ALDH1A1 118/4885ALDH2 445/4885ALDH3A1 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.