Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20999196 | 0.95 | ATF4 (0.59) | ATF4CYP1A2CYP3A4L3MBTL1MEN1 | |
| SCHEMBL22669132 | 0.90 | ATF4 (0.53) | ATF4L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL20999620 | 0.87 | ATF4 (0.50) | ATF4L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL20999171 | 0.84 | ATF4 (0.47) | ATF4L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL22669501 | 0.81 | ATF4 (0.57) | ATF4L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL21116380 | 0.81 | NPC1 (0.53) | ATF4CYP1A2CYP3A4L3MBTL1MEN1 | |
| SCHEMBL22669234 | 0.80 | ATF4 (0.42) | ATF4CYP1A2CYP3A4L3MBTL1MEN1 | |
| SCHEMBL19569416 | 0.79 | ATF4 (0.86) | ATF4CYP1A2CYP3A4L3MBTL1MEN1 | |
| SCHEMBL20999053 | 0.78 | ALDH1A1 (0.47) | L3MBTL1ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL22669375 | 0.78 | POLB (0.51) | ATF4ALDH1A1TSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ATF4 1/4885CYP1A2 2965/4885CYP3A4 3526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.