Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 10/20 | 0.46 |
| ▸ | LPL | P06858 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223530 | 0.86 | LIPG (0.40) | LIPGLPLALDH1A1P4HBHTT | |
| SCHEMBL13274950 | 0.85 | LIPG (0.40) | LIPGLPLALDH1A1P4HBF2 | |
| SCHEMBL14672713 | 0.83 | LIPG (0.51) | LIPGLPLALDH1A1GLATSHR | |
| SCHEMBL4221810 | 0.82 | LIPG (0.43) | LIPGLPLP4HBF2F11 | |
| SCHEMBL1316218 | 0.80 | LIPG (0.52) | LIPGLPLALDH1A1F11ROCK1 | |
| SCHEMBL19463268 | 0.80 | LIPG (0.52) | LIPGLPLF11ROCK1 | |
| SCHEMBL4753530 | 0.78 | LIPG (0.40) | LIPGLPLP4HBF2F11 | |
| SCHEMBL13274599 | 0.78 | LIPG (0.35) | LIPGLPLP4HBF2F11 | |
| SCHEMBL2262334 | 0.78 | CASR (0.44) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL23781315 | 0.78 | LIPG (0.50) | LIPGLPLALDH1A1P4HBROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |
| EP-1833836-A1 | IMIDAZO-FUSED THIAZOLO [4,5-B] PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Brystol-Myers Squibb Company (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006053120-A1 | IMIDAZO-FUSED THIAZOLO[4,5-b]PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-18 | — | — | WO | disclosed |