Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.40 |
| ▸ | LPL | P06858 | 4/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | F11 | P03951 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2136697 | 0.83 | LIPG (0.46) | LIPGLPLP4HBF2F11 | |
| SCHEMBL175277 | 0.83 | BACE1 (0.39) | BACE1 | |
| SCHEMBL4221810 | 0.82 | LIPG (0.43) | LIPGLPLP4HBF2F11 | |
| SCHEMBL1558987 | 0.80 | PDGFRB (0.37) | LIPGLPLP4HBF2F11 | |
| SCHEMBL2267172 | 0.78 | LIPG (0.46) | LIPGLPLP4HBF2F11 | |
| SCHEMBL59027 | 0.77 | F11 (0.39) | LIPGLPLP4HBF2F11 | |
| SCHEMBL1554719 | 0.76 | DGAT1 (0.37) | LIPGLPLP4HBF2F11 | |
| SCHEMBL58297 | 0.76 | AAK1 (0.44) | LIPGLPLP4HBF2F11 | |
| SCHEMBL59978 | 0.76 | ROCK1 (0.42) | LIPGLPLP4HBF2F11 | |
| SCHEMBL3766206 | 0.76 | LIPE (0.32) | F2F11PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255184-A1 | Thienopyridine B-Raf Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-10-16 | — | — | US | disclosed |
| EP-1951728-A2 | THIENOPYRIDINE B-RAF KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056625-A2 | THIENOPYRIDINE B-RAF KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255184-A1 | Thienopyridine B-Raf Kinase Inhibitors | BRAF, RAF1, ARAF | LIPG 3794/4885LPL 4636/4885P4HB 3984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.