Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2266798 | 1.00 | HRH3 (0.51) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1789991 | 0.91 | HRH3 (0.51) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1789988 | 0.91 | HRH3 (0.51) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1791368 | 0.91 | HRH3 (0.51) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2191319 | 0.91 | HRH3 (0.48) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2191302 | 0.91 | HRH3 (0.48) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2269194 | 0.89 | HRH3 (0.49) | HRH3HRH1LMNA | |
| SCHEMBL2223911 | 0.89 | HRH3 (0.49) | HRH3HRH1LMNA | |
| SCHEMBL1789947 | 0.89 | HRH3 (0.52) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2268812 | 0.88 | ADRA1A (0.51) | HRH3PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | disclosed |