Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.52 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.51 |
| ▸ | FLT3 | P36888 | 12/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283636 | 0.97 | CHEK1 (0.53) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL1916538 | 0.92 | CHEK1 (0.53) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL27403015 | 0.88 | ULK1 (0.52) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL3339984 | 0.88 | STK17A (0.51) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL3290772 | 0.88 | CHEK1 (0.58) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL3305264 | 0.88 | CHEK1 (0.51) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL1917792 | 0.88 | ULK1 (0.55) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL3283074 | 0.88 | STK17A (0.64) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL3289500 | 0.88 | STK17A (0.52) | ULK1ULK2CHEK1FLT3KIT | |
| SCHEMBL1917610 | 0.88 | CHEK1 (0.50) | ULK1ULK2CHEK1FLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231806-A1 | PHENYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2020-11-19 | — | — | WO | disclosed |