Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.51 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 16/20 | 0.49 |
| ▸ | FLT3 | P36888 | 15/20 | 0.49 |
| ▸ | KIT | P10721 | 4/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.45 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.45 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1917610 | 0.99 | CHEK1 (0.50) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL1917882 | 0.93 | ULK1 (0.55) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL1916758 | 0.91 | CHEK1 (0.50) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL1917119 | 0.90 | ULK1 (0.48) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL3305264 | 0.90 | CHEK1 (0.51) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL3283074 | 0.89 | STK17A (0.64) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL1918823 | 0.89 | CHEK1 (0.49) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL3335498 | 0.89 | ULK1 (0.46) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL1918370 | 0.88 | LRRK2 (0.50) | STK17AULK1ULK2CHEK1FLT3 | |
| SCHEMBL22673265 | 0.88 | ULK1 (0.52) | STK17AULK1ULK2CHEK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420630-B2 | Pyrimidine derivatives | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2013-04-16 | — | — | US | disclosed |
| EP-2090571-B1 | Pyrimidine derivates, medicaments comprising them, their use and process of their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 2012-05-16 | — | — | EP | disclosed |
| US-20100152167-A1 | PYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
| EP-1438053-B1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-09-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152167-A1 | PYRIMIDINE DERIVATIVES | TYMP, TYMS, DPYD | STK17A 1083/4885ULK1 1959/4885ULK2 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.