Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.46 |
| ▸ | TEK | Q02763 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.42 |
| ▸ | FYN | P06241 | 3/20 | 0.42 |
| ▸ | VCP | P55072 | 2/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22658885 | 0.87 | KDR (0.44) | KDRSRCEGFRRPS6KA3TEK | |
| SCHEMBL22675996 | 0.81 | SRC (0.53) | KDRSRCEGFRTEKKIT | |
| SCHEMBL25129546 | 0.81 | BTK (0.44) | KDRRPS6KA3TEKRPS6KB1FYN | |
| SCHEMBL22658573 | 0.78 | FGFR1 (0.60) | KDRSRCEGFRRPS6KA3TEK | |
| SCHEMBL29407661 | 0.78 | FGFR1 (0.60) | KDRSRCEGFRRPS6KA3TEK | |
| SCHEMBL29407781 | 0.77 | SRC (0.55) | KDRSRCEGFRTEKLCK | |
| SCHEMBL22677981 | 0.77 | SRC (0.55) | KDRSRCEGFRTEKLCK | |
| SCHEMBL20198773 | 0.75 | BTK (0.46) | EGFRRETFLT3BLKERBB4 | |
| SCHEMBL22676116 | 0.73 | KDR (0.47) | KDRSRCEGFRRPS6KA3TEK | |
| SCHEMBL24458853 | 0.73 | RET (0.47) | KDRSRCEGFRABL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306529-A2 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |