Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.53 |
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ABL2 | P42684 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 6/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29407669 | 0.85 | SRC (0.52) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL22658699 | 0.85 | SRC (0.52) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL22677178 | 0.81 | KDR (0.47) | SRCKDRABL1EGFRTEK | |
| SCHEMBL24458853 | 0.80 | RET (0.47) | SRCKDRABL1EGFRPI4KB | |
| SCHEMBL22676745 | 0.74 | SRC (0.67) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL5506725 | 0.74 | ADORA2A (0.70) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL130752 | 0.74 | NUDT14 (0.74) | SRCKDRABL1EGFRTEK | |
| SCHEMBL25129546 | 0.73 | BTK (0.44) | KDRABL1TEKPRKDCLCK | |
| SCHEMBL30582549 | 0.73 | RIPK2 (0.49) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL26107090 | 0.73 | RIPK2 (0.49) | SRCKDRABL1EGFRABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |