Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 17/20 | 0.44 |
| ▸ | ABL1 | P00519 | 14/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.44 |
| ▸ | EGFR | P00533 | 12/20 | 0.44 |
| ▸ | HCK | P08631 | 12/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.44 |
| ▸ | MTOR | P42345 | 12/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.44 |
| ▸ | PRKDC | P78527 | 12/20 | 0.44 |
| ▸ | KDR | P35968 | 11/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 11/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458871 | 0.88 | RET (0.47) | RETKIF5BDYRK1ASRCABL1 | |
| SCHEMBL22675996 | 0.80 | SRC (0.53) | SRCABL1PIK3CDEGFRHCK | |
| SCHEMBL24458348 | 0.78 | RET (0.56) | RETKIF5BDYRK1ASRCABL1 | |
| SCHEMBL130481 | 0.78 | PIK3CD (0.71) | SRCABL1PIK3CDEGFRHCK | |
| SCHEMBL29552386 | 0.77 | RET (0.44) | RETKIF5BDYRK1ASRCABL1 | |
| SCHEMBL29552528 | 0.76 | RET (0.43) | RETKIF5BDYRK1ASRCABL1 | |
| SCHEMBL21467054 | 0.73 | ABL1 (0.64) | SRCABL1PIK3CDEGFRHCK | |
| SCHEMBL22677178 | 0.73 | KDR (0.47) | RETDYRK1ASRCABL1PIK3CD | |
| SCHEMBL31523756 | 0.71 | RET (0.48) | RETKIF5BKDR | |
| SCHEMBL18521742 | 0.71 | ERBB2 (0.46) | SRCABL1EGFRHCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109551-A1 | SRC INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |