Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12775966 | 0.79 | AKT1 (0.37) | NPSR1L3MBTL1PARP1KDM4ESTAT3 | |
| SCHEMBL17541159 | 0.79 | NNMT (0.60) | NNMTDRD1MKNK1RETKDR | |
| SCHEMBL12590774 | 0.77 | SPR (0.39) | NPSR1PARP1KDM4EALDH1A1 | |
| SCHEMBL14320242 | 0.75 | NNMT (0.46) | NNMTPARP1KDM4EKDM4CALDH1A1 | |
| SCHEMBL12590744 | 0.74 | PRKACA (0.41) | NPSR1L3MBTL1PARP1KDM4ESTAT3 | |
| SCHEMBL27879194 | 0.73 | NPSR1 (0.35) | NPSR1L3MBTL1KDM4ESTAT3HIF1A | |
| SCHEMBL2600057 | 0.71 | DRD1 (0.49) | NNMTDRD1MKNK1RETKDR | |
| SCHEMBL12776648 | 0.71 | ENPP1 (0.44) | KDM4EALDH1A1 | |
| SCHEMBL3507179 | 0.69 | EGFR (0.44) | NNMTDRD1RETEGFRERBB2 | |
| SCHEMBL3506856 | 0.69 | EGFR (0.49) | NNMTRETEGFRERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |