Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734237 | 0.82 | BTK (0.46) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL13737164 | 0.82 | BTK (0.46) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL5527336 | 0.82 | BTK (0.46) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL25041953 | 0.82 | BTK (0.46) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL15122679 | 0.81 | BTK (0.44) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL24831927 | 0.81 | BTK (0.44) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL6644209 | 0.80 | CES2 (0.50) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL12519778 | 0.80 | CES2 (0.50) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL29191927 | 0.80 | DRD2 (0.44) | DRD2BTKKMT2AL3MBTL1EPHX1 | |
| SCHEMBL1137190 | 0.78 | BTK (0.45) | DRD2BTKKMT2AL3MBTL1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738954-A1 | METHOD OF PREPARATION OF SUBSTITUTED 2,4-DIAMINO-PYRIMIDINE-5-CARBOXAMIDES | Signal Pharmaceuticals, LLC (US) | 2020-11-18 | — | — | EP | disclosed |