SCHEMBL22685204

SCHEMBL22685204

Nc1cc(Cl)cnc1-c1ccc(C2(N)CC2)cc1

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 19/20 0.41
AKT2 P31751 8/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22685372 0.78 KDM4E (0.40) AKT1AKT2
SCHEMBL17110530 0.75 ADORA2A (0.47)
SCHEMBL22685246 0.73 WDR91 (0.45) AKT1
SCHEMBL17680402 0.70 SLC6A4 (0.42) AKT1AKT2
SCHEMBL668905 0.68 SLC6A4 (0.47) AKT2
SCHEMBL28414743 0.67 PTGS1 (0.52)
SCHEMBL29456722 0.67 PTGS1 (0.52)
Hydrochloric Acid SCHEMBL1919156 0.66 SLC6A4 (0.45) AKT2
SCHEMBL22685208 0.66 HTT (0.35) AKT1AKT2
SCHEMBL5570125 0.66 TDP1 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020228823-A1 NOVEL AMIDE COMPOUNDS AND USES THEREOF HUTCHISON MEDIPHARMA LIMITED (CN) 2020-11-19 WO disclosed