⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22686127 | 0.77 | MARK3 (0.37) | — | |
| SCHEMBL21053947 | 0.74 | BRD4 (0.38) | — | |
| SCHEMBL21054112 | 0.73 | CYP11B1 (0.33) | — | |
| SCHEMBL22686138 | 0.71 | — | — | |
| SCHEMBL22717065 | 0.69 | HTT (0.33) | — | |
| SCHEMBL21053191 | 0.67 | PDE3B (0.42) | — | |
| SCHEMBL22717121 | 0.66 | — | — | |
| SCHEMBL9322559 | 0.65 | ACHE (0.42) | — | |
| SCHEMBL22686136 | 0.65 | MB (0.42) | — | |
| SCHEMBL22716980 | 0.63 | NNMT (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200369667-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. | 2020-11-26 | — | — | US | disclosed |
| CN-111741964-A | Heterocyclic compounds as PRMT5 inhibitors | 安杰斯制药公司 | 2020-10-02 | — | — | CN | disclosed |