Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23585052 | 0.81 | THRB (0.54) | THRBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL21466271 | 0.74 | THRB (0.68) | THRBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18704269 | 0.72 | THRB (0.66) | THRBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14938490 | 0.71 | — | — | |
| SCHEMBL14938491 | 0.71 | — | — | |
| SCHEMBL11978610 | 0.70 | LMNA (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9973625 | 0.69 | THRB (0.61) | THRBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9973626 | 0.68 | THRB (0.59) | THRBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9572437 | 0.68 | TSHR (0.41) | THRBALDH1A1TSHRPTGS1 | |
| SCHEMBL12194917 | 0.67 | CYP2D6 (0.50) | MAPTALDH1A1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842459-A1 | ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF | ImmunoGen, Inc. (US) | 2021-06-30 | — | — | EP | disclosed |
| EP-3313884-B9 | ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF | IMMUNOGEN INC (US) | 2021-05-19 | — | — | EP | disclosed |
| EP-3313884-B1 | ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF | IMMUNOGEN INC (US) | 2020-11-18 | — | — | EP | disclosed |