SCHEMBL22689293

SCHEMBL22689293

O=C1N[C@@H]2CN(c3ccc(N4CC(Cn5ccnn5)OC4=O)cc3F)C[C@@H]2O1

nearest known ligand 0.69

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAOA P21397 16/20 0.69
MAOB P27338 1/20 0.69
KCNH2 Q12809 1/20 0.62
CYP3A4 P08684 3/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C9 P11712 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22689292 1.00 MAOA (0.69) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL22689304 0.89 MAOA (0.55) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL22689305 0.89 MAOA (0.55) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL6486990 0.88 MAOA (0.78) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL14480152 0.83 MAOA (0.78) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL14339477 0.83 MAOA (0.75) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL5459647 0.83 MAOA (0.75) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL5238029 0.83 MAOA (0.81) MAOAMAOBKCNH2CYP3A4CYP2D6
SCHEMBL22698634 0.82 MAOB (0.46) MAOAMAOB
SCHEMBL22698631 0.82 MAOB (0.46) MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020234636-A1 NOVEL COMPOUNDS FOR THE TREATMENT OF MAMMALIAN INFECTIONS CADILA HEALTHCARE LIMITED (IN) 2020-11-26 WO claimed
WO-2020234636-A1 NOVEL COMPOUNDS FOR THE TREATMENT OF MAMMALIAN INFECTIONS CADILA HEALTHCARE LIMITED (IN) 2020-11-26 WO disclosed