Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 2/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2263325 | 0.92 | ENPP2 (0.33) | ENPP2MEN1KMT2A | |
| SCHEMBL2361416 | 0.92 | ENPP2 (0.34) | CREBBPBRD4ENPP2MEN1KMT2A | |
| SCHEMBL2334239 | 0.91 | ENPP2 (0.34) | CREBBPENPP2MEN1KMT2ACHRM1 | |
| SCHEMBL2272785 | 0.90 | ENPP2 (0.35) | ENPP2MEN1KMT2APDE10AMET | |
| SCHEMBL2221804 | 0.90 | ENPP2 (0.35) | ENPP2MEN1KMT2APDE10AMET | |
| SCHEMBL13275446 | 0.88 | RAB9A (0.37) | ENPP2MEN1KMT2ACHRM1PDE10A | |
| SCHEMBL2221942 | 0.88 | ENPP2 (0.35) | ENPP2MEN1KMT2APDE10AMET | |
| SCHEMBL13507143 | 0.87 | ENPP2 (0.33) | ENPP2MEN1KMT2A | |
| SCHEMBL2221339 | 0.87 | IGF1R (0.33) | ENPP2MEN1KMT2APDE10AMET | |
| SCHEMBL2272546 | 0.87 | ENPP2 (0.33) | ENPP2MEN1KMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |