Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22803134 | 0.81 | — | — | |
| SCHEMBL22695465 | 0.71 | MAP4K1 (0.44) | MAP4K1 | |
| SCHEMBL31515402 | 0.70 | PDE7A (0.38) | ALDH1A1 | |
| SCHEMBL17348473 | 0.69 | NR3C2 (0.57) | ALDH1A1KMT2ASMN1; SMN2HSD17B10TP53 | |
| SCHEMBL24427221 | 0.67 | HTT (0.45) | ALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL17348471 | 0.66 | KDM4E (0.36) | ALDH1A1KMT2ASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL25247621 | 0.65 | PIM1 (0.32) | — | |
| SCHEMBL24307261 | 0.65 | MMP12 (0.50) | ALDH1A1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL24306751 | 0.65 | MMP12 (0.50) | ALDH1A1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL24307026 | 0.65 | POLB (0.33) | HPGDTP53NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237025-A1 | SUBSTITUTED EXO-METHYLENE-OXINDOLES WHICH ARE HPK1/MAP4K1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2020-11-26 | — | — | WO | disclosed |