⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22695462 | 0.81 | ALDH1A1 (0.39) | — | |
| SCHEMBL22803132 | 0.74 | MAP4K1 (0.42) | — | |
| SCHEMBL22803133 | 0.73 | NR3C2 (0.52) | — | |
| SCHEMBL22803135 | 0.69 | ALDH1A1 (0.35) | — | |
| SCHEMBL31515402 | 0.66 | PDE7A (0.38) | — | |
| SCHEMBL22792864 | 0.65 | ADRA2A (0.33) | — | |
| SCHEMBL12212773 | 0.63 | CRBN (0.31) | — | |
| SCHEMBL24427221 | 0.63 | HTT (0.45) | — | |
| SCHEMBL22803124 | 0.63 | ADRA2A (0.49) | — | |
| SCHEMBL17026912 | 0.61 | BRD4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037342-B2 | Substituted eneoxindoles and uses thereof | GILEAD SCIENCES, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037342-B2 | Substituted eneoxindoles and uses thereof | GILEAD SCIENCES, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-20230183262-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
| US-20230183262-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
| US-20200392153-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2020-12-17 | — | — | US | disclosed |